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Positive Surgical Margins at Radical Prostatectomy Predict positive surgical margins at radical prostatectomy predict

Positive surgical margins were associated with a 2.6-fold increased unadjusted risk of prostate cancer specific mortality (HR 2.55, 95% CI 2.02-3.21). Positive surgical margins remained an independent predictor of prostate cancer specific mortality on multivariate analysis (HR 1.70, 95% CI 1.32-2.18). Conclusions These data demonstrate the independent role of positive surgical margins in prostate

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Positive surgical margins at radical prostatectomy positive surgical margins at radical prostatectomy predict

Introduction. Positive surgical margins (PSM) at the time of radical prostatectomy (RP) are independent predictors of biochemical recurrence, local recurrence, distant metastasis and, in some series, have been shown to predict for prostate cancer specific mortality. 1 6 The occurrence of PSM often prompts adjuvant treatments, such as radiotherapy, which has been shown to improve positive surgical margins at radical prostatectomy predict

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Positive Surgical Margins at Radical Prostatectomy Predict positive surgical margins at radical prostatectomy predict

Jun 01, 2010 · Positive Surgical Margins at Radical Prostatectomy Predict Prostate Cancer Specific Mortality Purpose. Positive surgical margins in men undergoing radical prostatectomy for prostate cancer are associated with an positive surgical margins at radical prostatectomy predict Materials and Methods. The SEER cancer registry data for patients diagnosed between positive surgical margins at radical prostatectomy predict

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Positive Surgical Margin after Radical Prostatectomy? What positive surgical margins at radical prostatectomy predict

A positive surgical margin (PSM) after radical prostatectomy occurs in around 10-31% of cases, so researchers are very interested in understanding the clinical importance of a PSM. A team of scientists and doctors in Norway recently published a paper examining the effect of PSMs on patient outcomes. The paper can be viewed here.

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Prognostic value of surgical margin status for biochemical positive surgical margins at radical prostatectomy predict

Abstract Objective We evaluated the preoperative parameters to predict a positive surgical margin (SM) at radical prostatectomy for patients with prostate cancer. In addition, the prognostic factors for biochemical recurrence were determined in patients with positive SMs.

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What does a positive surgical margin actually predict positive surgical margins at radical prostatectomy predict

Feb 06, 2010 · Maybe 20-30 percent of all prostate cancer patients will be told, today, after a radical prostatectomy, that they a have a positive surgical margin. But exactly what impact a positive surgical margin has on a patients risk for disease recurrence has never been very clear. So that we are very clear, a positive surgical margin is an area on the edge of the prostate specimen, after surgical removal

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Positive surgical margins following radical prostatectomy positive surgical margins at radical prostatectomy predict

Apr 16, 2016 · The incidence of positive surgical margins increases in cases of extracapsular extension, which occurs when cancer cells break through the prostate capsule. To eliminate the cancer, the surgeon may need to make a wider cut around the prostate, possibly sacrificing the

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Understanding Surgical Margins after Radical Prostatectomy

Dec 21, 2015 · In an ideal world, after radical prostatectomy, your pathologist would send a triumphant report to your surgeon declaring you cancer-free. For some patients, however, the pathologist's report is more ambiguous. It may describe your margins, which are the edges of your removed tumor, as positive because they show some cancer cells.

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Cancer Resection and Surgical Margins Robotic positive surgical margins at radical prostatectomy predict

Aug 04, 2010 · The Decline of Positive Surgical Margins over Time Oncologic results from selected large contemporary open (retropubic and perineal) and standard laparoscopic radical prostatectomy series are listed in table I [25-31]. Positive margin rate ranged from 9%-24%. The largest series from Johns Hopkins, had 9035 RPs with 14.7% positive margins.

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Positive surgical margins at radical prostatectomy predict positive surgical margins at radical prostatectomy predict

Positive surgical margins at radical prostatectomy predict prostate cancer-specific mortality support for optimizing surgical technique and pathological evaluation at radical prostatectomy Jonathan L Wright , 1, 2 Bruce L. Dalkin , 1 Lawrence D True , 3 William J Ellis , 1 Janet L Stanford , 2 Paul H Lange , 1 and Daniel W Lin 1, 2

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Positive surgical margins in radical prostatectomy positive surgical margins at radical prostatectomy predict

Introduction. While positive surgical margins (PSMs) after radical prostatectomy (RP) are consistently and independently associated with higher risk of biochemical recurrence (BCR) 1-3, the impact of PSMs on longterm outcomes including metastasis, castrateresistant prostate cancer (CRPC), and prostate cancerspecific mortality (PCSM) remains less clear with mixed results in prior positive surgical margins at radical prostatectomy predict

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Cerenkov luminescence imaging can accurately assess positive surgical margins at radical prostatectomy predict

Oct 07, 2020 · A new intraoperative imaging technique, Cerenkov luminescence imaging (CLI), can accurately assess surgical margins during radical prostatectomy, according to a first-in-human research published positive surgical margins at radical prostatectomy predict

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Positive surgical margins in radical prostatectomy positive surgical margins at radical prostatectomy predict

Positive surgical margins in radical prostatectomy patients do not predict long-term oncological outcomes Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. BJU international , 117 (2), 244-248.

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Positive surgical margins at radical prostatectomy predict positive surgical margins at radical prostatectomy predict

Positive surgical margins at radical prostatectomy predict prostate cancer-specific mortality support for optimizing surgical technique and pathological evaluation at radical prostatectomy Jonathan L Wright , 1, 2 Bruce L. Dalkin , 1 Lawrence D True , 3 William J Ellis , 1 Janet L Stanford , 2 Paul H Lange , 1 and Daniel W Lin 1, 2

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Positive Surgical Margins After Radical Prostatectomy A positive surgical margins at radical prostatectomy predict

Positive surgical margins (PSMs) after radical prostatectomy (RP) are uniformly considered an adverse outcome associated with failure of the surgery to achieve cure of the prostate cancer (PCa). In 2009, we published a comprehensive review on the issue of positive margins that was based primarily on studies conducted in the late 1990s and early positive surgical margins at radical prostatectomy predict

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Predictors of Biochemical Failure Following Radical positive surgical margins at radical prostatectomy predict

Conclusions Among patients with positive surgical margins after radical prostatectomy, those with pre-op PSA>20ng/ml or more than one positive margins are at greater risk of biochemical or/and clinical failure. In these patients, starting salvage radiotherapy after surgery might be considered as a

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Positive surgical margins following radical prostatectomy positive surgical margins at radical prostatectomy predict

Apr 16, 2016 · The incidence of positive surgical margins increases in cases of extracapsular extension, which occurs when cancer cells break through the prostate capsule. To eliminate the cancer, the surgeon may need to make a wider cut around the prostate, possibly sacrificing the

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Positive surgical margins and biochemical recurrence positive surgical margins at radical prostatectomy predict

Oct 02, 2017 · Positive surgical margins are a strong prognostic marker of disease outcome following radical prostatectomy, though prior evidence is largely from a PSA-screened population. We therefore aim to evaluate the biochemical recurrence in men with positive surgical margins (PSM) after minimally-invasive radical prostatectomy (MIRP) in a UK tertiary centre. Retrospective study of men

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Frequency of Positive Surgical Margin at Prostatectomy

A positive surgical margin at prostatectomy is defined as tumor cells touching the inked edge of the specimen. This finding is reported in 8.8% to 42% of cases (median about 20%) in various studies. It is one of the main determinants of eventual biochemical (PSA) failure, generally associated with a doubled or tripled risk of failure.

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Positive Margins after Radical Prostatectomy - Now What positive surgical margins at radical prostatectomy predict

Jul 13, 2016 · Does a radical prostatectomy with positive margins spread cancer ? positive surgical margins at radical prostatectomy predict these tables use your data post op, PSA, Gleason score and stage to predict your probability of biochemical recurrence at 3, 5, 7 and 10 years positive surgical margins at radical prostatectomy predict The question is can surgery that results in positive margins actually hasten the spread of cancer in the body by exposing positive surgical margins at radical prostatectomy predict

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Radical prostatectomy and positive surgical margins positive surgical margins at radical prostatectomy predict

Positive surgical margins (PSMs) are an adverse factor that may predict a worse outcome in patients submitted to radical prostatectomy (RP). However, not all of these cases will evolve to biochemical (BCR) or clinical (CR) recurrence, therefore relationship between PSMs and these recurrent events has to be correlated with other clinical and positive surgical margins at radical prostatectomy predict

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Prognostic Value of Focal Positive Surgical Margins After positive surgical margins at radical prostatectomy predict

Background The significance of focal positive margins (FPMs) after radical prostatectomy (RP) is unclear. Our objective was to investigate the prognostic value of FPMs in patients undergoing RP. Materials and methods The data were analyzed retrospectively for 1733 patients with clinically localized prostate cancer who had undergone RP at our institution from December 2003 to March 2014 positive surgical margins at radical prostatectomy predict

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Prostate Cancer Surgery Positive Margins

Dec 03, 2019 · When surgical margins are positive, several studies show that immediate radiation to the prostate fossa will lower the relapse rates and may slightly improve ten-year survival rates. However, since only 50% of men will relapse, waiting for evidence of a PSA rise before starting radiation may be a reasonable alternative.

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Cerenkov luminescence imaging identifies surgical margin positive surgical margins at radical prostatectomy predict

Intraoperative 68Ga-PSMA Cerenkov Luminescence Imaging for Surgical Margins in Radical Prostatectomy A Feasibility Study. Journal of Nuclear Medicine , 2020; 61 (10) 1500 DOI 10.2967/jnumed.119 positive surgical margins at radical prostatectomy predict

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